Vice President, Product Team Leader

About the position At Day One, we are focused on advancing first- or best-in-class medicines for childhood and adult diseases with equal intensity. We were founded to address the lack of new therapies resulting from the traditional drug development model, that has left children with cancer and their families waiting too long for new, life-changing treatments. Our aim is to accelerate better, targeted treatments so patients of any age can look forward from ‘day one’ to the future they’ve envisioned. POSITION SUMMARY: We are seeking a strategic VP, Product Team Leader (PTL) to lead one or more cross-functional clinical-stage development program from Phase 1 through commercialization. The PTL will be responsible for establishing the long-term vision and strategy while enabling teams to achieve strong execution of the program plan through a close-collaboration with a cross-functional core team of Program Management, R&D, CMC and commercial leaders ensuring achievement of the program goals. The ideal candidate will be a strategic and flexible leader well-versed in drug development, with established pharmaceutical industry executive experience, innate cross-functional collaboration skills, and a commitment to scientific excellence, The candidate must be a strong influencer who can integrate effectively and align stakeholders across different functions and the Executive and Operating Committees. Reporting to the Head of R&D, as a member of the Research and Development Leadership Team you will champion the program with significant executive visibility and potential for patient impact globally This position should be based in either the San Francisco Bay Area, or the greater Boston area, with the expectation of at least two days/week in the office. Occasional travel will also be expected for in-person meetings. For the ideal candidate, a remote location to either San Francisco or Boston may be considered, however increased travel may be required in this instance. Responsibilities • Lead strategy creation and alignment of internal and external experts with overall product vision for one or more Day One product teams, resulting in a comprehensive Integrated Development Plan, ensuring all program initiatives are in pursuit of a coherent product vision. • Hold primary accountability for the forward progress of Day One’s development programs, as measured by the achievement of milestones and other key performance indicators defined by the Product Team (PT) and endorsed by senior leadership, effectively balancing scientific, regulatory and commercial objectives • Work closely with functional leaders and relevant sub-teams, leading the PT in development, evolution, and execution of an integrated global strategic project plan, including scientific, clinical, regulatory, CMC, commercial, and corporate/business considerations, doing so through building trusted relationships and ensuring alignment in pursuit of program and corporate goals • Communicate program strategy, progress, milestones, timelines, budget and drive decisions in senior leadership forums such as the Operating Committee. Distill program strategy and progress for presentation to key stakeholders such as the Board of Directors • In partnership with Clinical Research, Medical Affairs, Commercial leadership and other relevant stakeholders, establish and maintain key external stakeholder relationships relevant to the programs and products success • In partnership with Program Management, set direction, milestones and goals for the team, ensuring program strategy is aligned with corporate objectives and functional strategies • Lead the PT in developing and meeting the requirements of the relevant target product profiles • Work with Program Management to create and maintain an integrated program timeline detailing the development paths to registration across treatment settings and geographies • Work with Program Management to monitor team goals and team effectiveness • Work with the PT and Program Management to ensure timely execution of the project plan within allocated • Anticipate major risks to achievement of key deliverables and put appropriate mitigation plans in place • Perform integrated scenario planning/assessment for the development plan • Work with medical affairs and the commercial organization on scientific messaging and competitive positioning • Support the commercial organization in forecasting, launch, and portfolio planning efforts • Lead the PT in development of cross-functional program budget and resource drivers and Long-Range Plan (LRP) assumptions and work with functional heads to ensure appropriate program resources are in place • Partner with the Head of R&D, other Product Team Leads, the R&D Leadership Team and other key stakeholders such as Finance, Commercial, and Technical Operations and People to iteratively optimize the Product Team-centered model across the Day One portfolio • Partner with the Head of R&D, Finance, the Head of the Program Management Organization, and other key stakeholders in support of portfolio prioritization tools and processes as needed to support Day One’s portfolio growth. Requirements • Advanced degree (e.g. MS, MD, PhD, PharmD, MBA or equivalent) in life sciences or commensurate experience strongly preferred: Bachelor’s degree is required • 15+ years of industry experience in drug development, including a comprehensive understanding of early- and late-stage clinical drug development, precision medicine and global regulatory requirements; the preferred candidate will have had direct functional or project-oriented experience across the spectrum of development, from late preclinical through marketing authorization, inclusive of life cycle management. • 5+ years of cross-functional project leadership in oncology drug development or rare disease • Understanding of the manufacturing considerations of small molecules, biologics and ADC therapeutics • Demonstrated ability to integrate and synthesize data, assess strategic alternatives, and forge alignment of functions and executive management across business objectives, development strategy, and operational plans • Experienced partnering across the spectrum of functional areas to advance program objectives and a demonstrated understanding of and appreciation for commercial requirements • Track record in leading teams to strong results in a matrix environment and demonstrated skills in motivation of teams • Ability to cultivate excellent cross-functional collaborations • Strategic thinker with strong decision-making and analytical skills • Excellent communication and influencing skills with a proven ability to work with executive management to obtain endorsement of development plans and budget/personnel support; the ideal candidate will translate a multidimensional asset strategy across all stakeholders, including the Board of Directors, incorporating both the competitive landscape and corporate objectives • Ability to perform in a fast-paced, dynamic, cross-functional, and mission-driven environment; prior work experience in small biotech highly Mission-driven leadership that fosters inspiring, high-performing teams acting with accountability and empowerment to achieve clear program goals is essential • Willingness to assume full product accountability for both the strategic and operational plan, including program budget management in pursuit of clear program objectives, is critical. • Foster and facilitate a culture where diverse perspectives are heard in pursuit of optimal decision making, with skills to negotiate through challenging conversations to achieve positive outcomes; Humility and high self-awareness carry a high premium in Day One’s culture Apply tot his job