[Remote] Sr. Manager, Clinical Bioinformatics

Note: The job is a remote job and is open to candidates in USA. 10x Genomics is committed to accelerating the understanding of biology through innovative tools for scientists. The Director of Clinical Bioinformatics will lead the design and implementation of computational pipelines and analytical frameworks to support clinical diagnostics, ensuring compliance and analytical rigor in clinical applications. Responsibilities • Partner with the Diagnostic Assay Development team to integrate informatics approaches into assay design, validation, and performance optimization • Drive biomarker discovery and translational analyses in large-scale clinical research studies, including partnerships with leading academic centers processing thousands of tumor and blood samples • Work with external collaborators to generate and interpret data that demonstrate clinical validity and utility • Implement robust statistical and computational frameworks to address batch effects, confounding variables, and data harmonization across studies • Serve as the bioinformatics representative in external 10xDx translational and clinical collaborations • Maintain deep familiarity with emerging bioinformatics methodologies and clinical genomics standards • Lead the design, implementation, and optimization of bioinformatics pipelines for single-cell and spatial genomics data, from raw data to clinical interpretation • Establish, maintain, and operate CLIA-compliant computational workflows, documentation, and quality systems in collaboration with the CLIA Laboratory Director • Be responsible for data quality control and patient data reporting • Develop and validate algorithms, statistical models, and quality metrics for clinical assay performance • Direct analytical validation of bioinformatics components in support of LDT assays • Ensure computational reproducibility, version control, and auditability aligned with CLIA and CAP standards • Build and lead a high-performing team of bioinformaticians, fostering technical excellence and accountability • Partner with broader R&D computational biology team for method development and platform improvements • Define team goals, deliverables, and metrics supporting diagnostic R&D milestones • Establish data management and computational infrastructure in collaboration with IT, Quality, and CLIA lab teams • Support publication-quality analyses and contribute to scientific manuscripts and presentations at major conferences • Work closely with clinical, laboratory, and assay development teams to design studies, interpret results, and implement findings into diagnostic workflows • Collaborate with regulatory and quality leaders to ensure data integrity and compliance in all analytical systems • Serve as the bioinformatics representative during audits, partner reviews, and cross-functional readiness assessments • Contribute to defining the broader clinical bioinformatics strategy and diagnostic roadmap for 10xDx Skills • Ph.D. in Bioinformatics, Computational Biology, Genomics, or a related field • Minimum 10 years of experience in bioinformatics for clinical or diagnostic applications, including leadership of high-impact computational teams • Deep expertise in NGS, single-cell, and/or spatial data analysis, from primary data processing through interpretation • Proficiency in R, Python, and major bioinformatics toolkits; familiarity with cloud or high-performance computing • Demonstrated success collaborating with experimental scientists and clinicians on translational and diagnostic projects • Strong publication record in computational biology, genomics, or diagnostics • Detail-oriented and quality-driven, with a deep respect for validation and rigor • Strategic thinker who also thrives in hands-on analytical and computational work • Effective communicator and collaborator across scientific, operational, and executive teams • Motivated by building new capabilities at the intersection of genomics, computation, and clinical medicine Benefits • Equity grants • Comprehensive health and retirement benefit programs • Annual bonus program or sales incentive program Company Overview • Cells are the basic unit of life. It was founded in 2012, and is headquartered in Pleasanton, California, US, with a workforce of 1001-5000 employees. Its website is Company H1B Sponsorship • 10x Genomics has a track record of offering H1B sponsorships, with 25 in 2025, 46 in 2024, 37 in 2023, 53 in 2022, 34 in 2021, 16 in 2020. Please note that this does not guarantee sponsorship for this specific role. Apply tot his job