Principal Scientist - Small Molecule Process Development
About the position
At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Responsibilities
• Invent synthetic routes and develop safe, robust, and cost-effective processes to manufacture synthetic and hybrid drug substances.
• Advance enabling technologies to accelerate pharmaceutical development and to improve sustainability and process efficiency.
• Support cGMP manufacturing and technology transfer to our internal manufacturing facilities and external contract manufacturers.
• Ensure process performance through process understanding, modeling and characterization.
• Contribute to and lead drug substance development teams by providing experimental results, technical updates, documentation, data interpretation, recommendations, etc.
• Work cross-functionally to deliver regulatory documents and support regulatory filings.
• Serve as a technical expert and keep current in the field of organic and process chemistry.
• Work effectively in a multi-disciplinary team of chemists, engineers and attribute scientists.
• Independently develop experimental and testing plans to advance program objectives within required timelines.
Requirements
• Bachelor's degree and 7 years of Scientific experience; Or Master's degree and 5 years of Scientific experience; Or Doctorate degree PhD OR PharmD OR MD and 2 years of Scientific experience.
Nice-to-haves
• Ph.D. in organic chemistry and/or biochemistry with a specialization in total synthesis, reaction methodology, mechanistic studies, biocatalysis, peptide chemistry, oligonucleotide chemistry, and/or conjugation chemistry.
• Post-doctoral experience in an academic laboratory or pharmaceutical/biotech industry.
• Experience at a pharmaceutical/biotechnology company as a process development scientist.
• Experience working with external contract development and manufacturing partners.
• Track record of peer-reviewed publications and research presentations.
• Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results.
• Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects.
Benefits
• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan.
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Flexible work models, including remote and hybrid work arrangements, where possible.
Apply Now
Apply Now
At Amgen, if you feel like you're part of something bigger, it's because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do. Since 1980, we've helped pioneer the world of biotech in our fight against the world's toughest diseases. With our focus on four therapeutic areas -Oncology, Inflammation, General Medicine, and Rare Disease- we reach millions of patients each year. As a member of the Amgen team, you'll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives. Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you'll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.
Responsibilities
• Invent synthetic routes and develop safe, robust, and cost-effective processes to manufacture synthetic and hybrid drug substances.
• Advance enabling technologies to accelerate pharmaceutical development and to improve sustainability and process efficiency.
• Support cGMP manufacturing and technology transfer to our internal manufacturing facilities and external contract manufacturers.
• Ensure process performance through process understanding, modeling and characterization.
• Contribute to and lead drug substance development teams by providing experimental results, technical updates, documentation, data interpretation, recommendations, etc.
• Work cross-functionally to deliver regulatory documents and support regulatory filings.
• Serve as a technical expert and keep current in the field of organic and process chemistry.
• Work effectively in a multi-disciplinary team of chemists, engineers and attribute scientists.
• Independently develop experimental and testing plans to advance program objectives within required timelines.
Requirements
• Bachelor's degree and 7 years of Scientific experience; Or Master's degree and 5 years of Scientific experience; Or Doctorate degree PhD OR PharmD OR MD and 2 years of Scientific experience.
Nice-to-haves
• Ph.D. in organic chemistry and/or biochemistry with a specialization in total synthesis, reaction methodology, mechanistic studies, biocatalysis, peptide chemistry, oligonucleotide chemistry, and/or conjugation chemistry.
• Post-doctoral experience in an academic laboratory or pharmaceutical/biotech industry.
• Experience at a pharmaceutical/biotechnology company as a process development scientist.
• Experience working with external contract development and manufacturing partners.
• Track record of peer-reviewed publications and research presentations.
• Demonstrated ability to work within a dynamic and interdisciplinary environment to achieve results.
• Excellent written and verbal communication skills, ability to multitask, effectively plan and follow through on complex projects.
Benefits
• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan.
• Stock-based long-term incentives.
• Award-winning time-off plans.
• Flexible work models, including remote and hybrid work arrangements, where possible.
Apply Now
Apply Now